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Running out of money is not the worst thing. Running out of ideas is the worst thing.
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Philanthropy should be structured like venture capital — high-risk, high-reward bets on breakthrough science.
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Napster was right about everything except the business model. The music industry proved us right 10 years later.
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I look for the next paradigm shift. File sharing, social networking, streaming — each one was dismissed before it was inevitable.
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Facebook wasn't about technology. It was about identity. People wanted to be themselves online.